Pentoxifylline Prevents Upregulation of Monocyte Tissue Factor in Renal Transplant Recipients Undergoing Post-graft Complications

Sophie Susen; Marc Hazzan; Myriam Labalette; Christophe Zawadzki; Jean Paul Dessaint; Gaston Lelièvre; Brigitte Jude; Christian Noël

doi:10.1055/s-0037-1614112

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2000; 84(05): 764-769
DOI: 10.1055/s-0037-1614112

Review Article

Schattauer GmbH

Pentoxifylline Prevents Upregulation of Monocyte Tissue Factor in Renal Transplant Recipients Undergoing Post-graft Complications

Sophie Susen

¹From the Laboratoire d’Hématologie, Lille, France

,

Marc Hazzan

²Service de Néphrologie-Hémodialyse-Transplantation, Lille, France

,

Myriam Labalette

³Laboratoire d’Immunologie, Centre Hospitalier Regional Universitaire, Lille, France

,

Christophe Zawadzki

¹From the Laboratoire d’Hématologie, Lille, France

,

Jean Paul Dessaint

³Laboratoire d’Immunologie, Centre Hospitalier Regional Universitaire, Lille, France

,

Gaston Lelièvre

²Service de Néphrologie-Hémodialyse-Transplantation, Lille, France

,

Brigitte Jude

¹From the Laboratoire d’Hématologie, Lille, France

,

Christian Noël

²Service de Néphrologie-Hémodialyse-Transplantation, Lille, France

› Author Affiliations

Abstract

Summary

Pentoxifylline (PTX) has been demonstrated to improve graft survival in renal transplant recipients undergoing post graft complications. As activated monocytes are possible initiators of vascular damage through tissue factor (TF) expression, we evaluated the monocyte TF expression and endothelium activation markers in 140 consecutive patients receiving cadaveric kidney grafts, randomized in a double-blind study comparing PTX versus placebo. Monocyte TF expression and plasma von Willebrand factor, tissue plasminogen activator, thrombomodulin and tumor necrosis factor-α (TNF-α) levels were determined before transplantation and each month after. Additional samplings were realized in case of acute rejection. TF and TNF-α expression were significantly modified after graft. In patients with complications, PTX prevented the increase of TF expression at month one, and after rejection episodes. Endothelium activation markers were significantly modified after graft and in patients with complications but PTX had no significant effect on their plasma levels. These results suggest that the protective effect of PTX on graft survival could be related to the prevention of monocyte TF upregulation associated with complications.

Key words

Pentoxyfilline - tissue factor - renal transplantation - endothelium

Full Text

References

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